Lovastatina Astral

Lovastatina Astral may be available in the countries listed below.

Ingredient matches for Lovastatina Astral

Lovastatin

Lovastatin is reported as an ingredient of Lovastatina Astral in the following countries:

• Peru

International Drug Name Search

ReliOn/Novolin R

Generic Name: insulin regular (IN soo lin REG yoo lar)

Brand Names: HumuLIN R, NovoLIN R, NovoLIN R Innolet, NovoLIN R PenFill, ReliOn/NovoLIN R

What is ReliOn/Novolin R (insulin regular)?

Insulin is a hormone that is produced in the body. It works by lowering levels of glucose (sugar) in the blood. Insulin regular is a short-acting form of insulin.

Insulin regular is used to treat diabetes.

Insulin regular may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about ReliOn/Novolin R (insulin regular)?

Take care not to let your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.

Also watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. Your blood sugar will need to be checked often, and you may need to adjust your insulin dose.

Never share an injection pen or cartridge with another person. Sharing injection pens or cartridges can allow disease such as hepatitis or HIV to pass from one person to another.

Insulin is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

Do not change the brand of insulin or syringe you are using without first talking to your doctor or pharmacist. Some brands of insulin regular and syringes are interchangeable, while others are not. Your doctor and/or pharmacist know which brands can be substituted for one another.

What should I discuss with my healthcare provider before using ReliOn/Novolin R (insulin regular)?

Do not use this medication if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar).

To make sure you can safely use insulin, tell your doctor if you have liver or kidney disease.

Tell your doctor about all other medications you use, including any oral (by mouth) diabetes medications.

Insulin regular is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

FDA pregnancy category B. Insulin is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether insulin regular passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use ReliOn/Novolin R (insulin regular)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.

Insulin regular is injected under the skin. You may be shown how to use injections at home. Do not self inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Choose a different place in your injection skin area each time you use this medication. Do not inject into the same place two times in a row.

Insulin regular should look as clear as water. Do not use the medication if has changed colors, looks cloudy, or has particles in it. Call your doctor for a new prescription.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Some types of insulin needles can be used more than once. But reusing needles increases your risk of infection. Used needles must be properly cleaned and inspected for bending or breakage. Ask your doctor or pharmacist whether you can reuse your insulin needles.

Never share an injection pen or cartridge with another person. Sharing injection pens or cartridges can allow disease such as hepatitis or HIV to pass from one person to another. Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, hunger, weakness, sweating, tremors, irritability, or trouble concentrating.

Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.

Also watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.

Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, drink alcohol, or skip meals. These things can affect your glucose levels and your dose needs may also change.

Your doctor may want you to stop taking insulin for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency.

Ask your doctor how to adjust your insulin dose if needed. Do not change your medication dose or schedule without your doctor's advice.

If your doctor changes your brand, strength, or type of insulin, your dosage needs may change. Ask your pharmacist if you have any questions about the new kind of insulin you receive at the pharmacy.

Carry an ID card or wear a medical alert bracelet stating that you have diabetes, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are diabetic.

Insulin is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

Storing unopened vials and cartridges: Keep in the carton and store in a refrigerator, protected from light. Unopened vials may also be stored at room temperature, away from heat and bright light.

Storing after your first use: Keep the "in-use" vials or cartridges at room temperature.

Do not freeze insulin regular, and throw away the medication if it has become frozen.

Throw away any insulin not used before the expiration date on the medicine label.

What happens if I miss a dose?

Since insulin regular is used before meals or snacks, you may not be on a timed dosing schedule. Whenever you use insulin regular, be sure to eat a meal or snack within 15 to 30 minutes. Do not use extra insulin to make up a missed dose.

It is important to keep insulin regular on hand at all times. Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An insulin overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

What should I avoid while using ReliOn/Novolin R (insulin regular)?

Do not change the brand of insulin regular or syringe you are using without first talking to your doctor or pharmacist. Avoid drinking alcohol. Your blood sugar may become dangerously low if you drink alcohol while using insulin regular.

ReliOn/Novolin R (insulin regular) side effects

Get emergency medical help if you have any of these signs of insulin allergy: itching skin rash over the entire body, wheezing, trouble breathing, fast heart rate, sweating, or feeling like you might pass out.

Hypoglycemia, or low blood sugar, is the most common side effect of insulin. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). Carry hard candy or glucose tablets with you in case you have low blood sugar.

Tell your doctor if you have itching, swelling, redness, or thickening of the skin where you inject insulin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ReliOn/Novolin R (insulin regular)?

Using certain medicines can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any of the following:

• 
  

  albuterol (Proventil, Ventolin);

  
  


• 
  

  clonidine (Catapres);

  
  


• 
  

  reserpine; or

  
  


• 
  

  beta-blockers such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.

  
  

These lists are not complete and there are many other medicines that can increase or decrease the effects of insulin on lowering your blood sugar. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More ReliOn/Novolin R resources

• ReliOn/Novolin R Side Effects (in more detail)
• ReliOn/Novolin R Use in Pregnancy & Breastfeeding
• ReliOn/Novolin R Drug Interactions
• ReliOn/Novolin R Support Group
• 0 Reviews for ReliOn/Novolin R - Add your own review/rating

• Humulin R MedFacts Consumer Leaflet (Wolters Kluwer)


• Humulin R Prescribing Information (FDA)


• Humulin R (Concentrated) MedFacts Consumer Leaflet (Wolters Kluwer)


• Novolin R Prescribing Information (FDA)

Compare ReliOn/Novolin R with other medications

• Diabetes, Type 1
• Diabetes, Type 2
• Diabetic Ketoacidosis
• Gestational Diabetes
• Growth Hormone Reserve Test
• Hyperkalemia
• Insulin Resistance Syndrome
• Nonketotic Hyperosmolar Syndrome

Where can I get more information?

• Your pharmacist can provide more information about insulin regular.

See also: ReliOn/Novolin R side effects (in more detail)

DDAVP Solution

Pronunciation: DES-moe-PRES-in
Generic Name: Desmopressin
Brand Name: DDAVP

DDAVP Solution is used for:

Managing bleeding in patients with certain bleeding disorders (eg, hemophilia A, type I von Willebrand disease). It is also used to manage temporarily increased thirst and urination caused by head injury or certain types of brain surgery, or to manage certain types of diabetes (cranial diabetes insipidus). It may also be used for other conditions as determined by your doctor.

DDAVP Solution is an antidiuretic hormone. It works by causing the kidneys to produce less urine.

Do NOT use DDAVP Solution if:

• you are allergic to any ingredient in DDAVP Solution


• you have moderate to severe kidney problems


• you have type IIB von Willebrand disease


• you have or have a history of low blood sodium levels (salt depletion)

Contact your doctor or health care provider right away if any of these apply to you.

Before using DDAVP Solution:

Some medical conditions may interact with DDAVP Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have severe drowsiness


• if you have a history of kidney problems, heart problems (eg, heart blood vessel problems), abnormal blood clots (eg, in the legs, lungs, eyes), or high blood pressure


• if you have cystic fibrosis, dehydration, fever, severe infection, vomiting or diarrhea, swelling or fluid retention, or abnormal blood electrolyte levels


• if you are exposed to very hot weather, are physically active, or drink a lot of water


• if you have recently had surgery in the head area

Some MEDICINES MAY INTERACT with DDAVP Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Carbamazepine, chlorpromazine, lamotrigine, narcotic analgesics (eg, codeine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), oxybutynin, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), or tricyclic antidepressants (eg, imipramine) because the risk of fluid overload with low blood sodium levels may be increased

Ask your health care provider if DDAVP Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use DDAVP Solution:

Use DDAVP Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• DDAVP Solution is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using DDAVP Solution at home, a health care provider will teach you how to use it. Be sure you understand how to use DDAVP Solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.


• Do not use DDAVP Solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.


• If you miss a dose of DDAVP Solution, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. Contact your doctor right away.

Ask your health care provider any questions you may have about how to use DDAVP Solution.

Important safety information:

• DDAVP Solution may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use DDAVP Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Follow the fluid intake instructions given to you by your health care provider very carefully. Serious side effects may occur if you drink too much liquid while taking DDAVP Solution.


• Check with your doctor if you experience infection, fever, vomiting, or diarrhea. Tell your doctor if you will be exposed to very hot weather, will be physically active, or will be increasing your water intake for any reason. The risk of low blood sodium levels may be increased.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Tell your doctor or dentist that you take DDAVP Solution before you receive any medical or dental care, emergency care, or surgery.


• Lab tests, including urine volume, blood electrolyte levels, or kidney function, may be performed while you use DDAVP Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use DDAVP Solution with caution in the ELDERLY and in CHILDREN; they may be more sensitive to its effects, especially water overload. Signs of water overload may include severe or persistent nausea or headache, vomiting, or unusual weight gain.


• DDAVP Solution should be used with extreme caution in CHILDREN younger than 12 years old if used for diabetes insipidus; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using DDAVP Solution while you are pregnant. It is not known if DDAVP Solution is found in breast milk. If you are or will be breast-feeding while you are using DDAVP Solution, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of DDAVP Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. No COMMON side effects have been reported with DDAVP Solution. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); burning, redness, swelling, or pain at the injection site; calf pain, tenderness, or swelling; chest pain; confusion; coughing up blood; fainting; loss of appetite; mental or mood changes (eg, agitation, irritability); muscle weakness, spasms, or cramps; nausea; one-sided numbness or weakness; personality changes; seizures; severe or persistent dizziness; slurred speech; swelling; unusual headache or restlessness; unusual tiredness or sluggishness; unusual weight gain; vision problems; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: DDAVP side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; persistent headache; sudden weight gain; trouble urinating; unusual drowsiness. DDAVP Solution may be harmful if swallowed.

Proper storage of DDAVP Solution:

Store DDAVP Solution in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Store away from heat, moisture, and light. Keep DDAVP Solution out of the reach of children and away from pets.

General information:

• If you have any questions about DDAVP Solution, please talk with your doctor, pharmacist, or other health care provider.


• DDAVP Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about DDAVP Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More DDAVP resources

• DDAVP Side Effects (in more detail)
• DDAVP Use in Pregnancy & Breastfeeding
• Drug Images
• DDAVP Drug Interactions
• DDAVP Support Group
• 6 Reviews for DDAVP - Add your own review/rating

Compare DDAVP with other medications

• Diabetes Insipidus
• Hemophilia A
• Primary Nocturnal Enuresis
• von Willebrand's Disease

Repliva 21/7

Pronunciation: EYE-urn/sux-IN-ic AS-id/VYE-ta-min C/FOE-lik AS-id/VYE-ta-min B 12
Generic Name: Iron/Succinic Acid/Vitamin C/Folic Acid/Vitamin B12
Brand Name: Examples include Chromagen Forte and Repliva 21/7

Accidental overdose of products that contain iron is a leading cause of fatal poisoning in children younger than 6 years old. Keep this and all medicines out of the reach of children. In case of accidental ingestion, call the poison control center or a doctor at once.

Repliva 21/7 is used for:

Treating certain types of anemia that can be helped by increasing the amount of iron in the body (eg, anemia caused by pregnancy, blood loss, low dietary iron, metabolic disease, surgery). It may also be used for other conditions as determined by your doctor.

Repliva 21/7 is a combination of vitamins and minerals. It works by replacing iron in the body.

Do NOT use Repliva 21/7 if:

• you are allergic to any ingredient in Repliva 21/7


• you have too much iron in your body (eg, hemosiderosis, hemochromatosis)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Repliva 21/7:

Some medical conditions may interact with Repliva 21/7. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have another type of anemia (eg, pernicious anemia, megaloblastic anemia, hemolytic anemia)


• if you have stomach or bowel problems (eg, inflammation, Crohn disease, ulcer), metabolism problems, porphyria, or a blood disease (eg, thalassemia)


• if you have had multiple blood transfusions

Some MEDICINES MAY INTERACT with Repliva 21/7. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Fluorouracil because the risk of its side effects may be increased by Repliva 21/7


• Doxycycline, hydantoins (eg, phenytoin), mycophenolate, penicillamine, or thyroid hormones (eg, levothyroxine) because their effectiveness may be decreased by Repliva 21/7

This may not be a complete list of all interactions that may occur. Ask your health care provider if Repliva 21/7 may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Repliva 21/7:

Use Repliva 21/7 as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Repliva 21/7 by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• Swallow Repliva 21/7 whole. Do not break, crush, or chew before swallowing.


• Take Repliva 21/7 with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Repliva 21/7.


• If you also take cefdinir, methyldopa, a quinolone antibiotic (eg, ciprofloxacin), or a tetracycline antibiotic (eg, minocycline), ask your doctor or pharmacist how to take it with Repliva 21/7.


• If you miss a dose of Repliva 21/7, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Repliva 21/7.

Important safety information:

• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Do not take large doses of vitamins while you take Repliva 21/7 unless your doctor tells you to.


• Repliva 21/7 may cause your stools to darken. This is normal and not a cause for concern.


• Repliva 21/7 may interfere with certain lab tests, such as tests used to check for blood in the stool. Make sure your doctor and lab personnel know you are using Repliva 21/7.


• Lab tests, including blood counts and iron levels, may be performed while you use Repliva 21/7. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Repliva 21/7 should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Repliva 21/7 while you are pregnant. Repliva 21/7 is found in breast milk. If you are or will be breast-feeding while you use Repliva 21/7, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Repliva 21/7:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; darkened or green stools; diarrhea; nausea; stomach upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood or streaks of blood in the stool; severe or persistent vomiting or stomach pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Repliva 21/7 side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include black, tarry stools; chest pain; coma; dizziness; fast heartbeat; fever; increased or decreased urination; increased thirst or hunger; seizures; severe nausea, vomiting, diarrhea, or stomach pain; shortness of breath; sluggishness; trouble breathing; unusual tiredness or drowsiness; unusually pale skin; weak pulse.

Proper storage of Repliva 21/7:

Store Repliva 21/7 at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Repliva 21/7 out of the reach of children and away from pets.

General information:

• If you have any questions about Repliva 21/7, please talk with your doctor, pharmacist, or other health care provider.


• Repliva 21/7 is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Repliva 21/7. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Repliva 21/7 resources

• Repliva 21/7 Side Effects (in more detail)
• Repliva 21/7 Use in Pregnancy & Breastfeeding
• Repliva 21/7 Drug Interactions
• Repliva 21/7 Support Group
• 2 Reviews for Repliva 21/7 - Add your own review/rating

• multivitamin with iron Concise Consumer Information (Cerner Multum)


• Allbee-C 800 with Iron Concise Consumer Information (Cerner Multum)


• Ferotrin Prescribing Information (FDA)


• Ferralet 90 Prescribing Information (FDA)


• Ferrex 150 Forte Prescribing Information (FDA)


• Ferrex 150 Forte Plus Prescribing Information (FDA)


• Ferrex 28 Prescribing Information (FDA)


• FerroGels Forte Prescribing Information (FDA)


• Hematogen Forte Prescribing Information (FDA)


• Integra F Prescribing Information (FDA)


• Integra Plus Prescribing Information (FDA)


• Irospan 24/6 Prescribing Information (FDA)


• NovaFerrum Prescribing Information (FDA)


• Tricon Prescribing Information (FDA)

Compare Repliva 21/7 with other medications

• Anemia
• Vitamin/Mineral Supplementation and Deficiency

Felison

Felison may be available in the countries listed below.

Ingredient matches for Felison

Flurazepam

Flurazepam monohydrochloride (a derivative of Flurazepam) is reported as an ingredient of Felison in the following countries:

• Italy

International Drug Name Search

Ranexa

Pronunciation: ra-NOE-la-zeen
Generic Name: Ranolazine
Brand Name: Ranexa

Ranexa is used for:

Treating chronic chest pain (angina). It may be used alone or in combination with other medicines.

Ranexa is an antianginal medicine. Exactly how it works is not known.

Do NOT use Ranexa if:

• you are allergic to any ingredient in Ranexa


• you have liver cirrhosis


• you are taking certain azole antifungals (eg, itraconazole, ketoconazole), barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), certain macrolide antibiotics (eg, clarithromycin), nefazodone, certain protease inhibitors (eg, indinavir, nelfinavir, ritonavir, saquinavir), a rifamycin (eg, rifampin), St. John's wort, or telithromycin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ranexa:

Some medical conditions may interact with Ranexa. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of liver problems, kidney problems or if you are on dialysis, or have diabetes


• if you have a personal or family history of irregular heartbeat (eg, prolonged QTc interval, congenital long QT syndrome), abnormal heart function tests, or low blood potassium levels


• if you take certain antipsychotics (eg, thioridazine, ziprasidone) or antiarrhythmics (eg, amiodarone, dofetilide, quinidine, sotalol), or any other medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat

Some MEDICINES MAY INTERACT with Ranexa. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Aprepitant, azole antifungals (eg, itraconazole, ketoconazole, fluconazole), cyclosporine, diltiazem, macrolide antibiotics (eg, clarithromycin, erythromycin), nefazodone, protease inhibitors (eg, boceprevir, ritonavir), telithromycin, or verapamil because they may increase the risk of Ranexa's side effects


• Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), rifamycins (eg, rifampin), or St. John's wort because they may decrease Ranexa's effectiveness


• Digoxin, lovastatin, simvastatin, sirolimus, tacrolimus, or tricyclic antidepressants (eg, amitriptyline) because the risk of their side effects may be increased by Ranexa

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ranexa may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ranexa:

Use Ranexa as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Ranexa by mouth with or without food.


• Swallow Ranexa whole. Do not break, crush, or chew before swallowing.


• Check with your doctor before you eat grapefruit or drink grapefruit juice while you are taking Ranexa.


• If you miss a dose of Ranexa, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Ranexa.

Important safety information:

• Ranexa may cause dizziness, light-headedness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Ranexa with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Ranexa may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Do NOT take more than the recommended dose without checking with your doctor.


• Ranexa is not effective in treating an angina attack. Talk to your doctor about how to treat an angina attack.


• Lab tests, including heart function, may be performed while you use Ranexa. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Ranexa with caution in the ELDERLY; they may be more sensitive to its effects.


• Ranexa should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ranexa while you are pregnant. It is not known if Ranexa is found in breast milk. Do not breast-feed while taking Ranexa.

Possible side effects of Ranexa:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; headache; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); blood in the urine; blurred vision; change in the amount of urine produced; chest pain; confusion; decreased sense of touch; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; numbness, burning, prickling, or tingling of the skin; severe or persistent dizziness, light-headedness, or weakness; shortness of breath; swelling of the hands or feet; tremor; unusual bruising or bleeding.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Ranexa side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; double vision; fainting; numbness, burning, prickling, or tingling of the skin; severe or persistent dizziness, nausea, or vomiting.

Proper storage of Ranexa:

Store Ranexa at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ranexa out of the reach of children and away from pets.

General information:

• If you have any questions about Ranexa, please talk with your doctor, pharmacist, or other health care provider.


• Ranexa is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Ranexa. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Ranexa resources

• Ranexa Side Effects (in more detail)
• Ranexa Use in Pregnancy & Breastfeeding
• Drug Images
• Ranexa Drug Interactions
• Ranexa Support Group
• 11 Reviews for Ranexa - Add your own review/rating

• Ranexa Prescribing Information (FDA)


• Ranexa Consumer Overview


• Ranexa Monograph (AHFS DI)


• Ranexa Advanced Consumer (Micromedex) - Includes Dosage Information


• Ranolazine Professional Patient Advice (Wolters Kluwer)

Compare Ranexa with other medications

• Angina

Roxal-Estradiol Derm 100

Generic Name: estrogen (Oral route, Parenteral route, Topical application route, Transdermal route)

Commonly used brand name(s)

In the U.S.

• Alora


• Cenestin


• Climara


• Divigel


• Elestrin


• Emcyt


• Enjuvia


• Esclim


• Estinyl


• EstroGel


• Evamist


• Femtrace


• Gynodiol


• Menest


• Menostar


• Ogen .625


• Ogen 1.25


• Ogen 2.5


• Premarin


• Vivelle


• Vivelle-Dot

In Canada

• Estraderm


• Estradot Transdermal


• Estradot Transdermal Therapeutic System


• Estradot Transdermal Therapeutic System


• Estrogel


• Oesclim


• Rhoxal-Estradiol Derm 50


• Rhoxal-Estradiol Derm 75


• Roxal-Estradiol Derm 100


• Vivelle 100 Mcg


• Vivelle 25 Mcg

Available Dosage Forms:

• Tablet


• Patch, Extended Release


• Gel/Jelly


• Spray


• Emulsion


• Tablet, Enteric Coated


• Capsule

Uses For Roxal-Estradiol Derm 100

Estrogens are female hormones. They are produced by the body and are necessary for the normal sexual development of the female and for the regulation of the menstrual cycle during the childbearing years.

The ovaries begin to produce less estrogen after menopause (the change of life). This medicine is prescribed to make up for the lower amount of estrogen. Estrogens help relieve signs of menopause, such as hot flashes and unusual sweating, chills, faintness, or dizziness.

Estrogens are prescribed for several reasons:

• To provide additional hormone when the body does not produce enough of its own, such as during menopause or when female puberty (development of female sexual organs) does not occur on time. Other conditions include a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), or ovary problems (female hypogonadism or failure or removal of both ovaries).


• To help prevent weakening of bones (osteoporosis) in women past menopause.


• In the treatment of selected cases of breast cancer in men and women.


• In the treatment of cancer of the prostate in men.

Estrogens may also be used for other conditions as determined by your doctor.

There is no medical evidence to support the belief that the use of estrogens will keep the patient feeling young, keep the skin soft, or delay the appearance of wrinkles. Nor has it been proven that the use of estrogens during menopause will relieve emotional and nervous symptoms, unless these symptoms are caused by other menopausal symptoms, such as hot flashes or hot flushes.

Estrogens are available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, estrogen is used in certain patients with the following medical conditions:

• Gender identity disorder, male-to-female transsexualism (person who is born as a man but adapts to a woman's lifestyle, sees himself as a woman, and feels like a woman instead of a man.


• Osteoporosis caused by lack of estrogen before menopause.


• Turner's syndrome (a genetic disorder).

Before Using Roxal-Estradiol Derm 100

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Use of this medicine before puberty is not recommended. Growth of bones can be stopped early. Girls and boys may develop growth of breasts. Girls may have vaginal changes, including vaginal bleeding.

This medicine may be used to start puberty in teenagers with some types of delayed puberty.

Geriatric

Elderly people are especially sensitive to the effects of estrogens. This may increase the chance of side effects during treatment, especially stroke, invasive breast cancer, and memory problems.

Pregnancy

Estrogens are not recommended for use during pregnancy or right after giving birth. Becoming pregnant or maintaining a pregnancy is not likely to occur around the time of menopause.

Certain estrogens have been shown to cause serious birth defects in humans and animals. Some daughters of women who took diethylstilbestrol (DES) during pregnancy have developed reproductive (genital) tract problems and, rarely, cancer of the vagina or cervix (opening to the uterus) when they reached childbearing age. Some sons of women who took DES during pregnancy have developed urinary-genital tract problems.

Breast Feeding

Use of this medicine is not recommended in nursing mothers. Estrogens pass into the breast milk and their possible effect on the baby is not known.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

• Rotavirus Vaccine, Live

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Adenovirus Vaccine Type 4, Live


• Adenovirus Vaccine Type 7, Live


• Bacillus of Calmette and Guerin Vaccine, Live


• Boceprevir


• Felbamate


• Influenza Virus Vaccine, Live


• Isotretinoin


• Measles Virus Vaccine, Live


• Mumps Virus Vaccine, Live


• Paclitaxel


• Paclitaxel Protein-Bound


• Rotavirus Vaccine, Live


• Rubella Virus Vaccine, Live


• Smallpox Vaccine


• St John's Wort


• Theophylline


• Tizanidine


• Tranexamic Acid


• Typhoid Vaccine


• Varicella Virus Vaccine


• Yellow Fever Vaccine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:

For all patients

• Asthma or


• Calcium, too much or too little in blood or


• Diabetes or


• Epilepsy or seizures or


• Heart problems or


• Kidney problems or


• Liver tumors, benign or


• Lupus erythematosus, systemic or


• Migraine headaches—Estrogens may worsen these conditions.

• Blood clotting problems, or history of during previous estrogen therapy—Estrogens usually are not used until blood clotting problems stop; using estrogens is not a problem for most patients without a history of blood clotting problems due to estrogen use.

• Breast cancer or


• Bone cancer or


• Cancer of the uterus or


• Fibroid tumors of the uterus—Estrogens may interfere with the treatment of breast or bone cancer or worsen cancer of the uterus when these conditions are present.

• Bulging eyes or


• Double vision or


• Migraine headache or


• Vision changes, sudden onset including or


• Vision loss, partial or complete—Estrogens may cause these problems. Tell your doctor if you have had any of these problems, especially while taking estrogen or oral contraceptives (“birth control pills”).

• Changes in genital or vaginal bleeding of unknown causes—Use of estrogens may delay diagnosis or worsen condition. The reason for the bleeding should be determined before estrogens are used.

• Endometriosis or


• Gallbladder disease or gallstones, or history of or


• High cholesterol or triglycerides, or history of or


• Liver disease, or history of or


• Pancreatitis (inflammation of pancreas) or


• Porphyria—Estrogens may worsen these conditions. Although estrogens can improve blood cholesterol, they can worsen blood triglycerides for some people.

• Hypothyroid (too little thyroid hormone)—Dose of thyroid medicine may need to be increased.

For males treated for breast or prostate cancer:

• Blood clots or


• Heart or circulation disease or


• Stroke—Males with these medical problems may be more likely to have clotting problems while taking estrogens; the high doses of estrogens used to treat male breast or prostate cancer have been shown to increase the chances of heart attack, phlebitis (inflamed veins) caused by a blood clot, or blood clots in the lungs.

Proper Use of estrogen

This section provides information on the proper use of a number of products that contain estrogen. It may not be specific to Roxal-Estradiol Derm 100. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it and do not take or use it for a longer time than your doctor ordered. For patients taking any of the estrogens by mouth, try to take the medicine at the same time each day to reduce the possibility of side effects and to allow it to work better.

This medicine usually comes with patient information or directions. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

For patients taking any of the estrogens by mouth or by injection:

• Nausea may occur during the first few weeks after you start taking estrogens. This effect usually disappears with continued use. If the nausea is bothersome, it can usually be prevented or reduced by taking each dose with food or immediately after food.

For patients using the transdermal (skin patch):

• Wash and dry your hands thoroughly before and after handling the patch.


• Apply the patch to a clean, dry, non-oily skin area of your lower abdomen, hips below the waist, or buttocks that has little or no hair and is free of cuts or irritation. The manufacturer of the 0.025-mg patch recommends that its patch be applied to the buttocks only. Furthermore, each new patch should be applied to a new site of application. For instance, if the old patch is taken off the left buttock, then apply the new patch to the right buttock.


• Do not apply to the breasts. Also, do not apply to the waistline or anywhere else where tight clothes may rub the patch loose.


• Press the patch firmly in place with the palm of your hand for about 10 seconds. Make sure there is good contact, especially around the edges.


• If a patch becomes loose or falls off, you may reapply it or discard it and apply a new patch.


• Each dose is best applied to a different area of skin on your lower abdomen, hips below the waist, or buttocks so that at least 1 week goes by before the same area is used again. This will help prevent skin irritation.

For patients using the topical emulsion (skin lotion):

• Washing and drying hands thoroughly before each application.


• Apply while you are sitting comfortably. Apply one pouch to each leg every morning.


• Apply the entire contents of one pouch to clean, dry skin on the left thigh. Rub the emulsion into the entire thigh and calf for 3 minutes until thoroughly absorbed.


• Apply entire contents of the second pouch to clean, dry skin on the right thigh. Rub the emulsion into the entire thigh and calf for 3 minutes until thoroughly absorbed.


• Rub any remaining emulsion on both hands on the buttocks.


• Washing and drying hands thoroughly after application.


• To avoid transfer to other individuals, allow the application areas to dry completely before covering with clothing.

If you are using the Evamist® transdermal spray:

• Spray the medicine on your skin on the inside of your forearm, between the elbow and the wrist.


• Do not allow your child to touch the area of the arm where the medicine was sprayed. If you cannot avoid to come nearer with your child, wear clothes with long sleeves to cover the application site.


• If your child comes in direct contact with the arm where the medicine was sprayed, wash your child's skin right away with soap and water.


• Do not allow your pets to lick or touch the arm where the medicine was sprayed.

Dosing

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For conjugated estrogens


• For oral dosage form (tablets):
  
  • For treating breast cancer in women after menopause and in men:
    
    • Adults—10 milligrams (mg) three times a day for at least 3 months.
    
    
  
  
  • For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), or symptoms of menopause:
    
    • Adults—0.3 milligram (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month. Your doctor may change the dose based on how your body responds to the medication.
    
    
  
  
  • To prevent loss of bone (osteoporosis):
    
    • Adults—0.3 milligram (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month. Your doctor may change the dose based on how your body responds to the medication.
    
    
  
  
  • For treating ovary problems (female hypogonadism or for starting puberty):
    
    • Adults and teenagers—0.3 to 0.625 milligram (mg) a day. Your doctor may want you to take the medicine only on certain days of the month.
    
    
  
  
  • For treating ovary problems (failure or removal of both ovaries):
    
    • Adults—1.25 milligram (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month.
    
    
  
  
  • For treating prostate cancer:
    
    • Adults—1.25 to 2.5 milligram (mg) three times a day.
    
    
  
  


• For injection dosage form:
  
  • For controlling abnormal bleeding of the uterus:
    
    • Adults—25 milligrams (mg) injected into a muscle or vein. This may be repeated in six to twelve hours if needed.
    
    
  
  

• For esterified estrogens


• For oral dosage form (tablets):
  
  • For treating breast cancer in women after menopause and in men:
    
    • Adults—10 milligrams (mg) three times a day for at least three months.
    
    
  
  
  • For treating a genital skin condition (vulvar atrophy) or inflammation of the vagina (atrophic vaginitis), or to prevent loss of bone (osteoporosis):
    
    • Adults—0.3 to 1.25 mg a day. Your doctor may want you to take the medicine each day or only on certain days of the month.
    
    
  
  
  • For treating ovary problems (failure or removal of both ovaries):
    
    • Adults—1.25 mg a day. Your doctor may want you to take the medicine each day or only on certain days of the month.
    
    
  
  
  • For treating ovary problems (female hypogonadism):
    
    • Adults—2.5 to 7.5 mg a day. This dose may be divided up and taken in smaller doses. Your doctor may want you to take the medicine each day or only on certain days of the month.
    
    
  
  
  • For treating symptoms of menopause:
    
    • Adults—0.625 to 1.25 mg a day. Your doctor may want you to take the medicine each day or only on certain days of the month.
    
    
  
  
  • For treating prostate cancer:
    
    • Adults—1.25 to 2.5 mg three times a day.
    
    
  
  

• For estradiol


• For oral dosage form:
  
  • For treating breast cancer in women after menopause and in men:
    
    • Adults—10 milligrams (mg) three times a day for at least 3 months.
    
    
  
  
  • For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), ovary problems (female hypogonadism or failure or removal of both ovaries), or symptoms of menopause:
    
    • Adults—At first, 1 to 2 milligrams (mg) one time per day for at least 3 months. Your doctor may want you to take the medicine each day or only on certain days of the month. Your doctor may also need to change the dose based on how your body responds to the medication.
    
    
  
  
  • For treating prostate cancer:
    
    • Adults—1 to 2 milligrams (mg) three times a day.
    
    
  
  
  • To prevent loss of bone (osteoporosis):
    
    • Adults—0.5 milligram (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month.
    
    
  
  


• For topical emulsion dosage form (skin lotion):
  
  • For treating symptoms of menopause:
    
    • Adults—1.74 grams (one pouch) applied to the skin of each leg (thigh and calf) once a day in the morning.
    
    
  
  


• For transdermal dosage form (skin patches):
  
  • For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), symptoms of menopause, ovary problems (female hypogonadism or failure or removal of both ovaries), or to prevent loss of bone (osteoporosis):
    
    • For the Climara patches
    
    
    • Adults—0.025 to 0.1 milligram (mg) (one patch) applied to the skin and worn for one week. Then, remove that patch and apply a new one. A new patch should be applied once a week for three weeks. During the fourth week, you may or may not wear a patch. Your health care professional will tell you what you should do for this fourth week. After the fourth week, you will repeat the cycle.
    
    
    • For the Alora, Estraderm, Estradot, Vivelle, or Vivelle-Dot patches
    
    
    • Adults—0.025 to 0.1 mg (one patch) applied to the skin and worn for one half of a week. Then, remove that patch and apply and wear a new patch for the rest of the week. A new patch should be applied two times a week for three weeks. During the fourth week, you may or may not apply new patches. Your health care professional will tell you what you should do for this fourth week. After the fourth week, you will repeat the cycle.
    
    
  
  

• For estradiol cypionate


• For injection dosage form:
  
  • For treating ovary problems (female hypogonadism):
    
    • Adults—1.5 to 2 milligrams (mg) injected into a muscle once a month.
    
    
  
  
  • For treating symptoms of menopause:
    
    • Adults—1 to 5 milligrams (mg) injected into a muscle every 3 to 4 weeks.
    
    
  
  

• For estradiol valerate


• For injection dosage form:
  
  • For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), symptoms of menopause, or ovary problems (female hypogonadism or failure or removal of both ovaries):
    
    • Adults—10 to 20 milligrams (mg) injected into a muscle every 4 weeks as needed.
    
    
  
  
  • For treating prostate cancer:
    
    • Adults—30 milligrams (mg) injected into a muscle every 1 or 2 weeks.
    
    
  
  

• For estrone


• For injection dosage form:
  
  • For controlling abnormal bleeding of the uterus:
    
    • Adults—2 to 5 milligrams (mg) a day, injected into a muscle for several days.
    
    
  
  
  • For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), or symptoms of menopause:
    
    • Adults—0.1 to 0.5 milligram (mg) injected into a muscle 2 or 3 times a week. Your doctor may want you to receive the medicine each week or only during certain weeks of the month.
    
    
  
  
  • For treating ovary problems (female hypogonadism or failure or removal of both ovaries):
    
    • Adults—0.1 to 1 milligram (mg) a week. This is injected into a muscle as a single dose or divided into more than one dose. Your doctor may want you to receive the medicine each week or only during certain weeks of the month.
    
    
  
  
  • For treating prostate cancer:
    
    • Adults—2 to 4 milligrams (mg) injected into a muscle 2 or 3 times a week.
    
    
  
  

• For estropipate


• For oral dosage form (tablets):
  
  • For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), or symptoms of menopause:
    
    • Adults—0.75 to 6 milligrams (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month.
    
    
  
  
  • For treating ovary problems (female hypogonadism or failure or removal of both ovaries):
    
    • Adults—1.5 to 9 milligrams (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month.
    
    
  
  
  • To prevent loss of bone (osteoporosis):
    
    • Adults—0.75 milligram (mg) a day. Your doctor may want you to take the medicine each day for twenty-five days of a thirty-one–day cycle.
    
    
  
  

• For ethinyl estradiol


• For oral dosage form (tablets):
  
  • For treating breast cancer in women after menopause and in men:
    
    • Adults—1 milligram (mg) three times a day.
    
    
  
  
  • For treating ovary problems (female hypogonadism or failure or removal of both ovaries):
    
    • Adults—0.05 milligram (mg) one to three times a day for 3 to 6 months. Your doctor may want you to take the medicine each day or only on certain days of the month.
    
    
  
  
  • For treating prostate cancer:
    
    • Adults—0.15 to 3 milligrams (mg) a day.
    
    
  
  
  • For treating symptoms of menopause:
    
    • Adults—0.02 to 0.05 milligram (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month.
    
    
  
  

• For ethinyl estradiol and norethindrone


• For oral dosage form (tablets):
  
  • For treating symptoms of menopause:
    
    • Adults—1 tablet (5 mcg ethinyl estradiol and 1 mg of norethindrone) each day.
    
    
  
  
  • To prevent loss of bone (osteoporosis):
    
    • Adults—1 tablet (5 mcg ethinyl estradiol and 1 mg of norethindrone) each day.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

If you forget to wear or change a patch, put one on as soon as you can. If it is almost time to put on your next patch, wait until then to apply a new patch and skip the one you missed. Do not apply extra patches to make up for a missed dose.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Roxal-Estradiol Derm 100

It is very important that your doctor check your progress at regular visits to make sure this medicine does not cause unwanted effects. These visits will usually be every year, but some doctors require them more often.

In some patients using estrogens, tenderness, swelling, or bleeding of the gums may occur. Brushing and flossing your teeth carefully and regularly and massaging your gums may help prevent this. See your dentist regularly to have your teeth cleaned. Check with your medical doctor or dentist if you have any questions about how to take care of your teeth and gums, or if you notice any tenderness, swelling, or bleeding of your gums.

Although the incidence is low, the use of estrogens may increase you chance of getting cancer of the breast, ovaries, or uterus (womb). Therefore, it is very important that you regularly check your breasts for any unusual lumps or discharge. Report any problems to your doctor. You should also have a mammogram (x-ray pictures of the breasts) done if your doctor recommends it. Because breast cancer has occurred in men taking estrogens, regular breast self-exams and exams by your doctor for any unusual lumps or discharge should be done.

If your menstrual periods have stopped, they may start again. This effect will continue for as long as the medicine is taken. However, if taking the continuous treatment (0.625 mg conjugated estrogens and 2.5 mg medroxyprogesterone once a day), monthly bleeding usually stops within 10 months.

Also, vaginal bleeding between your regular menstrual periods may occur during the first 3 months of use. Do not stop taking your medicine. Check with your doctor if bleeding continues for an unusually long time, if your period has not started within 45 days of your last period, or if you think you are pregnant.

Tell the doctor in charge that you are using this medicine before having any laboratory test because some results may be affected.

Check with your child's doctor right away if your child starts to have the following symptoms: nipple or breast swelling or tenderness in females, or enlargement of the breasts in males. Your child may have been exposed to Evamist® transdermal spray.

Do not allow your pets to lick or touch the arm where Evamist® transdermal spray was applied. Small pets may be sensitive to this medicine. Call your pet's veterinarian if your pet starts to have the following symptoms: nipple or breast enlargement, swelling of the vulva, or any signs of illness.

Roxal-Estradiol Derm 100 Side Effects

Women rarely have severe side effects from taking estrogens to replace estrogen. Discuss these possible effects with your doctor:

The prolonged use of estrogens has been reported to increase the risk of endometrial cancer (cancer of the lining of the uterus) in women after menopause. This risk seems to increase as the dose and the length of use increase. When estrogens are used in low doses for less than 1 year, there is less risk. The risk is also reduced if a progestin (another female hormone) is added to, or replaces part of, your estrogen dose. If the uterus has been removed by surgery (total hysterectomy), there is no risk of endometrial cancer.

Although the incidence is low, the use of estrogens may increase you chance of getting cancer of the breast. Breast cancer has been reported in men taking estrogens.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

The following side effects may be caused by blood clots, which could lead to stroke, heart attack, or death. These side effects occur rarely, and, when they do occur, they occur in men treated for cancer using high doses of estrogens.

Check with your doctor immediately if any of the following side effects occur:

More common

• Breast pain (in females and males)


• fast heartbeat


• fever


• hives


• hoarseness


• increased breast size (in females and males)


• irritation of the skin


• itching of the skin


• joint pain, stiffness, or swelling


• rash


• redness of the skin


• shortness of breath


• swelling of the eyelids, face, lips, hands, or feet


• swelling of the feet and lower legs


• tightness in the chest


• troubled breathing or swallowing


• weight gain (rapid)


• wheezing

Less common or rare

• Changes in vaginal bleeding (spotting, breakthrough bleeding, prolonged or heavier bleeding, or complete stoppage of bleeding)


• chest pain


• chills


• cough


• heavy non-menstrual vaginal bleeding


• lumps in, or discharge from, breast (in females and males)


• pains in the stomach, side, or abdomen


• yellow eyes or skin

Rare - for males being treated for breast or prostate cancer only

• Headache (sudden or severe)


• loss of coordination (sudden)


• loss of vision or change of vision (sudden)


• pains in the chest, groin, or leg, especially in the calf of leg


• shortness of breath (sudden and unexplained)


• slurring of speech (sudden)


• weakness or numbness in the arm or leg

Incidence not known

• Abdominal or stomach bloating


• abdominal or stomach cramps


• acid or sour stomach


• anxiety


• backache


• belching


• blindness


• blistering, peeling, or loosening of the skin


• blue-yellow color blindness


• blurred vision


• change in vaginal discharge


• changes in skin color


• changes in vision


• chest discomfort


• clay-colored stools


• clear or bloody discharge from nipple


• confusion


• constipation


• convulsions


• dark urine


• decrease in the amount of urine


• decreased vision


• depression


• diarrhea


• difficulty with breathing


• difficulty with speaking


• dimpling of the breast skin


• dizziness


• double vision


• dry mouth


• eye pain


• fainting


• fluid-filled skin blisters


• full feeling in upper abdomen or stomach


• full or bloated feeling or pressure in the stomach


• headache


• heartburn


• inability to move the arms, legs, or facial muscles


• inability to speak


• incoherent speech


• increased urination


• indigestion


• inverted nipple


• irregular heartbeats


• light-colored stools


• lightheadedness


• loss of appetite


• loss of bladder control


• lump under the arm


• metallic taste


• migraine headache


• mood or mental changes


• muscle cramps in the hands, arms, feet, legs, or face


• muscle pain


• muscle spasm or jerking of all extremities


• muscle weakness


• nausea


• noisy breathing


• numbness or tingling of the hands, feet, or face


• pain in the ankles or knees


• pain or discomfort in the arms, jaw, back or neck


• pain or feeling of pressure in the pelvis


• pain, tenderness, swelling of the foot or leg


• painful or tender cysts in the breasts


• painful, red lumps under the skin, mostly on the legs


• pains in the chest, groin, or legs, especially calves of the legs


• partial or complete loss of vision in the eye


• pelvic pain


• persistent crusting or scaling of nipple


• pinpoint red or purple spots on the skin


• prominent superficial veins over affected area


• red, irritated eyes


• redness or swelling of the breast


• sensitivity to the sun


• severe headaches of sudden onset


• skin thinness


• skin warmth


• slow speech


• sore on the skin of the breast that does not heal


• sore throat


• sores, ulcers, or white spots in the mouth or on the lips


• stomach discomfort, upset, or pain


• sudden loss of consciousness


• sudden loss of coordination


• sudden onset of shortness of breath for no apparent reason


• sudden onset of slurred speech


• sudden vision changes


• swelling of the abdominal or stomach area


• swelling of the fingers or hands


• thirst


• tremor


• unpleasant breath odor


• unusual tiredness or weakness


• vomiting


• vomiting of blood


• weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Abnormal growth filled with fluid or semisolid material


• accidental injury


• bladder pain


• bloated full feeling


• bloody or cloudy urine


• body aches or pain


• coating or white patches on tongue


• congestion


• cough producing mucus


• decrease in amount of urine


• difficult, burning, or painful urination


• discouragement


• dryness of the throat


• ear congestion or pain


• excess air or gas in the stomach or intestines


• fear


• feeling of warmth


• feeling sad or empty


• frequent urge to urinate


• general feeling of discomfort or illness


• headache, severe and throbbing


• increased clear or white vaginal discharge


• irritability


• itching of the vaginal, rectal or genital areas


• lack of appetite


• lack or loss of strength


• loss of interest or pleasure


• mild dizziness


• neck pain


• nervousness


• pain


• pain during sexual intercourse


• painful or difficult urination


• pain or tenderness around the eyes and cheekbones


• passing gas


• redness of the face, neck, arms, and occasionally, upper chest


• runny nose


• skin irritation or redness where skin patch was worn


• shivering


• sleeplessness


• sneezing


• sore mouth or tongue


• stuffy nose


• sudden sweating


• tender, swollen glands in the neck


• thick, white vaginal discharge with no odor or with a mild odor


• tiredness


• trouble concentrating


• trouble sleeping


• unable to sleep


• voice changes

Less common

• Blemishes on the skin


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• burning or stinging of the skin


• diarrhea (mild)


• difficulty with moving


• dizziness (mild)


• increased hair growth, especially on the face


• lower abdominal or stomach pain or pressure


• mood or mental changes


• muscle stiffness


• painful cold sores or blisters on the lips, nose, eyes, or genitals


• pimples


• pounding in the ears


• problems in wearing contact lenses


• slow heartbeat


• tooth or gum pain


• unusual decrease in sexual desire (in males)


• unusual increase in sexual desire (in females)


• white or brownish vaginal discharge

Incidence not known

• Abnormal turning out of cervix


• changes in appetite


• dull ache or feeling of pressure or heaviness in the legs


• flushed, dry skin


• fruit-like breath odor


• increased hunger


• irritability


• large amount of triglyceride in the blood


• leg cramps


• patchy brown or dark brown discoloration of the skin


• poor insight and judgment


• problems with memory or speech


• trouble recognizing objects


• trouble thinking and planning


• trouble walking


• twitching, uncontrolled movements of the tongue, lips, face, arms, or legs


• unexpected or excess milk flow from the breasts

Also, many women who are taking estrogens with a progestin (another female hormone) will start having monthly vaginal bleeding, similar to menstrual periods, again. This effect will continue for as long as the medicine is taken. However, monthly bleeding will not occur in women who have had the uterus removed by surgery (total hysterectomy).

This medicine may cause loss or thinning of the scalp hair in some people.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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